Hope you enjoy your new mp...
well the cursor keys are very important for your workflow to be functional in an easy way.
Do not put pressure on them as this might destroy the inner soldered connections or anything.
I experienced this problem twice in my MPC's life.
Best thing IMO is to open the mpc's case
get the faceplate of and try to see if they will respond by pushing the switches directly with your finger
In my case the did respond well and all I needed was something inbetween my switches and the plastic buttons (folded paper

)
Hopefully your problem will not serious but try this to check.
The other case woyld be a destroyed solder connection. Simple solution to that a sldering iron and some solder and you are done.
An indication for this might be that it is a bit loose or something like that. You would be able to see it once you open it up
PS. when you pen it you need to take of the plastic bit of keys to see the switches (as of in the 2k xl of mine)