Delta 44 + Nuendo issues

I just recently came up on a Delta 44 soundcard and everything seems cool until I try to run it with Nuendo. I'm not sure whether it is the ASIO driver or what, but the card seems to be alright with the other programs. It keeps locking up my computer. I've downloaded the newest drivers from www.m-audio.com and still no dice. Anybody know what's up?

Try increasing the buffer size. I've had trouble running Cubase SL (same audio engine as nuendo) w. very low latency.