I bet it is that adapted Ploytech POS driver. Well before the Ren even released I half jokingly said I bet Akai adapts a Ploytech driver in response to at the time our resident Akai unpaid Yes man/troll/village idiot.
After the Ren released I forgot all about it, but another member pulled out the 9 month old quotes from me. I was just thinking, aww man I hope this doesn't cause all these Ren adopters issues.
I don't use a Ren but I've had three different interfaces with adapted Ploytech drivers and every one of the would lose sample rate sync and just crap out in the middle of doing basic things with low USB stack CPU load.
Again I don't use the Ren, and I used to use ASIO4All in place of the Ploytech adapted drivers, which I've heard doesn't really work on the Ren. If other USB devices seem to be contributing to the issues, maybe try to look at your computers USB bus architecture. Figure out which port has the shortest line to the motherboard. I had that minimize issues with Ploytech and other drivers in the past.