do you have another computer you can try ren with ?, this would help isolating the problem.
if you search online there's a case of complaints for issues with akai's audio interface: hiss/static pop and all that jazz...some users here earlier on also experienced issues with the interface
http://www.amazon.com/Akai-Professional-EIE-Pro-Electromusic/dp/B004MZOVKOI've used ren's interface on 2007 and 2010 macpro and it worked without any major issues