Midi handshake is a pretty standard term in the electronic music vocabulary. As two cables are required there is nothing automatic about it.
A small extract taken from MPC-Tutor's excellent guide
Understanding midi on the Akai MPChttp://www.mpc-tutor.com/article/9/unde ... -akai-mpc/Connecting up a keyboard with sounds (synthesiser)
"If you have a keyboard with its own sounds, like a Korg Triton for example, you can still control the MPC samples as you did in the last example. This is because any synthesiser keyboard will transmit MIDI information. Just remember that the main difference here will be that your keyboard in this situation can also emit sounds itself - so make sure you turn off the synthesiser's volume control, otherwise you'll not only hear the MPC internal samples, but also the synth's sounds as well!
The main thing I want to show here is that a synth not only has a MIDI out, it also has a MIDI IN - hence it can not only send MIDI information, it can also RECEIVE it. Equally, our MPC not only receives MIDI information, it can also TRANSMIT it. This means that we can send a MIDI information signal to our synth from our MPC and this signal can (amongst other things) tell our synth to play a particular note. How do we send a MIDI signal from our MPC? Well, the PADs all have a unique MIDI note number so when you press a PAD, it's the same as pressing a key on a MIDI keyboard. For example, PAD A1 is by default MIDI Note 37 - if a MIDI synth is connected to your MPC and you press PAD A1, it will play MIDI note 37 (C#) in our synth.
This time, as well as connecting the keyboard MIDI out to the MPC MIDI in, you connect the MPC MIDI out to the keyboard MIDI in.
This is called the MIDI 'handshake'.
So, press a PAD on the MPC and a MIDI instruction travels from the MPC MIDI out to the synth MIDI in. Upon receiving it, the synth plays the appropriate note which in turn is outputted as audio through the synth's audio outputs.
Equally, you could press a key on the synth and this will transmit a MIDI instruction to the MPC. Upon receiving this instruction, the MPC could play an internal sample (should one exist at that MIDI note number) which would be outputted out of the MPC audio outs (if connected)".