Yes! A little background: I'm a drummer and came to producing beats after moving out of mama's house. I couldn't bring my drums to my apartment but still wanted to hit something.

I've always been a hip-hop head and really wanted to get into digging for records and sampling. It's my new addiction!
I started with the MPC 500, which is a great machine after upgrading the stock pads. I then wanted some computer integration, since I'm a computer nerd anyway. The Ren is a substantial investment for an amateur musician IMHO, but it's worth it if you really know you'll put the time into using it. The first time I chopped a sample and saw it all "come together" when throwing some drums over it... let me tell you that's a golden moment!
I've since built a more powerful PC for the Ren after using it on my laptop (with a few crashes when using VSTs). I also began using Ableton Live, which is awesome as well. I always be coming back to the Ren for its sampler, pads, and track mute. Vintage mode is awesome as well, especially because you can demo it "live" to see how your beat sounds with it on.
My experience is probably not typical, as I'm sure others have come to the Ren after years in computer music production. Honestly, once I figured out how to use my MPCs, I was blown away with how quick the workflow was. It's a lot of fun to use when my musician friends come over and want to sample their own playing or rhyme over a beat.
I really only have a couple gripes. I wish the Ren were cheaper, but it's everything I could ever need (maybe more). Using the device on Windows 7 (32-bit on laptop and 64-bit on the new desktop), there have been some crashes and lost work. However, I work in the IT field. I understand hardware/software doesn't always work 100% of the time, so I'm understanding. As long as the Ren is mostly stable (which it has been), I'm happy.
My setup: Numark NS6 DJ controller/mixer is connected to the Ren for sampling. I run a mic, turntable, and my PC into the mixer. As for output, I'm using my good ol' Logitech speakers from college. Say what you want about my "monitors," but for now they're good enough for me!