Hi, at work at the moment but will recount as my memory allows.

Mac OSx Mountain lion 10.8
MPC version and firmware newest-all up to date
MPC via D Link 7 port USB hub (i think, not at home to check), but mayeb through Mac direct.
Yamaha 16 input desk > behringer firewire soundcard >mac
MPC audio direct through USB to Mac.
multiple USB synths connected to USB hub: novation basstation,waldorf blofeld, waldorf rocket, monome 256, Akai MPK mini keyboard
Set up has always worked, yes. One issue I did have was my other Akai mini keyboard, the editor kept opening as a max/msp patch, and i am led to believe that was maybe an audio driver conflict?
It appears the kernel crashes happen when i am running patches using max/msp and i am using my monome as well. This is integral to my set up to use my monome as well as the Ren at the same time, ad I have never had issues. After every crash, when rebooting the MPC software, a box appears saying that 'audio preferences have changed'. When I go to MPC preferences my soundcard shows up as it always has done?
When i am home, i will try and open MPC on its own and see if the kernel crash happens or i get the info asking me to change audio preferences.
I believ there is a conflict with max/msp. I uninstalled my MPK mini editor as i couldn't get it to open outside of Max.