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i dont have a 4k so im not sure- but i dont think you can
i don;t think there is a definite answer if you can isolated vocals
i think it depends on the way it was originally recorded.
i remember when i was young and grimy i used to **** with headphone adapters and don't leave them plugged in all the way but just enough where you can hear a little sound , you can isolate certain sounds.
also some older stereo records might have isolated vocals on one speaker channel.
there is one complicated tequnique where you can isolate vocals from a beat if you give a **** check out innaspace acapellas on sounclick. check the ones that say diy . i think to do this you need the instrumental version of the song and the regular W/vocals and mix it down some how