you can get attacks that will search out ports (usually internal ID's on a board) as well as external drvies connected via USB!
i've been very cautious with my usage when connecting cause of this.
my biggest tip is to get some Spyware, something you actually have to pony up some money for cause they search much deeper and have a team updating regularly.
here's a decent free one that i run in conjunction with Virus wares>
Free AdAware >
http://www.lavasoftusa.com/support/download/
$30 Spyware >
http://www.spywareremove.com/
i ran the free AdAware for a few months, finally broke down and bought the other one and it searched much much deeper : pulled something like 34 objects that Adawre missed. now i run them both : still not catching everything i'm sure...
as well, i disconnect the LAN on my OS prior to making the USB connection. i drag, drop and manage but make sure to unplug ASAP. i don't let the machine sit while i doodle on the 4K so that way i cut down on the possibilty the system runs a timed Operation (like virus sweep or disc clean-up). also : turn the HIBERNATION mode off on your CPU, sometimes AKsys will hang if your system sleeps.
all of this should help cut down the fragmentation and the possibility of contamination on your music. good luck!